1-[2-(trifluoromethyl)phenyl]methanesulfonamide

1-[2-(trifluoromethyl)phenyl]methanesulfonamide - Names and Identifiers

Name	2-(Trifluoromethyl)benzylsulfonamide
Synonyms	2-(TRIFLUOROMETHYL)BENZYLSULFONAMIDE 2-(Trifluoromethyl)benzylsulfonamide 2-(Trifluoromethyl)Benzenemethane Sulfonamide Benzenemethanesulfonamide, 2-(trifluoromethyl)- 1-[2-(trifluoromethyl)phenyl]methanesulfonamide
CAS	112941-35-2
InChI	InChI=1/C8H8F3NO2S/c9-8(10,11)7-4-2-1-3-6(7)5-15(12,13)14/h1-4H,5H2,(H2,12,13,14)

1-[2-(trifluoromethyl)phenyl]methanesulfonamide - Physico-chemical Properties

Molecular Formula	C8H8F3NO2S
Molar Mass	239.21
Density	1.458±0.06 g/cm3(Predicted)
Boling Point	326.0±52.0 °C(Predicted)
Flash Point	151°C
Vapor Presure	0.000221mmHg at 25°C
pKa	10.11±0.60(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.507

1-[2-(trifluoromethyl)phenyl]methanesulfonamide - Introduction

2-(Trifluoromethyl) benzylsulfonamide (abbreviated as TFMSA) is an organic compound with the chemical formula C8H6F3NO2S. The following is a description of the nature, use, method and safety information of TFMSA:

Nature:
1. Appearance: TFMSA is a colorless to light yellow crystalline solid or powder.
2. Solubility: TFMSA is soluble in common organic solvents such as ether, methanol, ethanol and chloroform.
3. Melting point: The melting point of TFMSA is 75-78 degrees Celsius.
4. Chemical properties: TFMSA has good stability and electrophilicity. It can be used as a strong acidic reagent and can react with bases to form the corresponding salts.

Use:
1. TFMSA is commonly used as a strong acidic reagent in organic synthesis for acid-catalyzed reactions, acylation reactions, and the generation of esters or ethers.
2. TFMSA can be used as a protective agent of cinnamic acid to protect its carboxyl functional groups in the synthesis process.
3. TFMSA can be used in the synthesis of benzylsulfonamide antibiotics.

Preparation Method:
The preparation of TFMSA is usually obtained by reacting 2-chloroethylbenzylsulfonamide with sodium trifluoromethanesulfonate in the presence of mercurous cyanide. The detailed preparation method can refer to the relevant organic synthesis literature.

Safety Information:
TFMSA is relatively stable under normal use, but the following safety precautions still need to be paid attention:
1. TFMSA may be irritating to the eyes, skin and respiratory system, so avoid contact and ensure good ventilation.
2. Avoid inhalation or ingestion of TFMSA, and seek medical attention immediately if inhaled or ingested.
3. Wear appropriate personal protective equipment such as gloves, protective clothing and goggles when using TFMSA.
4. TFMSA should be stored in a cool, ventilated and dry place, away from fire and oxidant.

This information is for informational purposes only. When using TFMSA, it is recommended to consult more reliable literature and guidelines and follow appropriate laboratory safety practices.

Last Update：2024-04-10 22:29:15